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Pain Management Drugs

Global Veterinary Pain Management Drugs Market Likely To Spearhead Growth By Rising Prevalence Of Animal Diseases

Mar 26, 2019 (American News Hour via COMTEX) —  “Global Veterinary Pain Management Drugs Market: Global Demand Analysis & Opportunity Outlook 2024”

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pain management drugsGlobal veterinary pain management drugs market is expected to flourish at a CAGR 0f 7.8% over the forecast period. Rising prevalence of animal diseases coupled with increasing number of veterinary hospitals and clinics are likely to spearhead the growth of the veterinary pain management drugs market. Moreover, the global veterinary pain management drugs market is expected to garner noteworthy revenue by the end of 2024.

The global veterinary pain management drugs market is segmented into opioids, agonists, Local Anesthetics, NSAIDs (Non-steroidal Anti Inflammatory Drugs), Disease-modifying Osteoarthritis Drugs (DMOAD) and others. Growing number of veterinary clinics and hospitals across the globe is aiding to the growth of veterinary pain management drugs market. Moreover, growing spending on pet healthcare is expected to accelerate the growth of the veterinary pain management drugs market in the upcoming years.

North America accounted for largest market share in overall veterinary pain management drugs market in 2016. Moreover, North America is expected to continue its dominance over the forecast period. Increasing number of veterinary practitioners in the region is believed to significantly increase the demand for veterinary pain management drugs during the forecast period. U.S. is witnessing the augmented demand for veterinary pain management drugs. Asia Pacific is also expected to showcase significant growth in the veterinary pain management drugs market. Increasing adoption of companion animals coupled with growth in number of veterinary clinics signals promising growth of veterinary pain management drugs market in the upcoming years.

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Growing Pet Ownership

Significant increase in the number of pet parents or pet owners who consider pet as a part of their family is anticipated to positively impact the growth of the market. For instance, As per PetSecure, more than 90% of the Americans consider pets as a part of their family. In addition, pet owners are spending more on the healthcare of pets due to their strengthening bond. This factor is anticipated to positively impact the growth of the Veterinary Pain Management Drugs Market.

Rising Number of Veterinarians Across the Globe

Rise in the number of veterinarians across the world is believed spearhead current and future market growth of Veterinary Pain Management Drugs during the forecast period. For instance, according to American Veterinary Medical Association, in U.S., the number of veterinarians increases from 92,547 in 2011 to 107,995 in 2016. Moreover, the number of veterinarians is expected to increase across the globe which is expected to drive the growth of the veterinary pain management drugs market.

However, increasing cost of veterinary pet care is expected to negatively impact the growth of the global veterinary pain management drugs market.

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The report titled “Global Veterinary Pain Management Drugs Market: Global Demand Analysis & Opportunity Outlook 2024″ delivers detailed overview of the global veterinary pain management drugs market in terms of market segmentation by product, by animal type, by application, by distribution channel and by region.

Further, for the in-depth analysis, the report encompasses the industry growth drivers, restraints, supply and demand risk, market attractiveness, BPS analysis and Porter’s five force model.

This report also provides the existing competitive scenario of some of the key players of the global veterinary pain management drugs market which includes company profiling of Boehringer Ingelheim, Zoetis, Inc. , Merck Animal Health , Elanco , Bayer AG, Vetoquinol S.A., Ceva Sante Animale, Virbac Group, Norbrook Laboratories Ltd, Dechra Pharmaceuticals and other key players . The profiling enfolds key information of the companies which encompasses business overview, products and services, key financials and recent news and developments. On the whole, the report depicts detailed overview of the Global veterinary Pain Management Drugs market that will help industry consultants, equipment manufacturers, existing players searching for expansion opportunities, new players searching possibilities and other stakeholders to align their market centric strategies according to the ongoing and expected trends in the future.

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The post Global Veterinary Pain Management Drugs Market likely to Spearhead Growth by Rising Prevalence of Animal Diseases appeared first on America News Hour.


Recro Pharma Falls As FDA Denies Approval To Pain Candidate

Shares of Recro Pharma, Inc. REPH plunged 34% on Mar 25, following a complete response letter (“CRL”) to the new drug application (“NDA”) seeking approval of its pain candidate, meloxicam. The company was looking to get this approval to the intravenous (“IV”) administration of meloxicam for the treatment of moderate to severe pain.

The FDA has cited that delayed onset of the candidate has failed to meet the prescriber expectations for IV drugs. Moreover, the regulatory authority raised concerns about the role of meloxicam monotherapy for acute pain, based on its interpretation of clinical data.

So far this year, shares of Recro Pharma have lost 9.7% against the industry’s 15.3% rally.

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We remind investors that this is second CRL for meloxicam. In May, the FDA had issued a CRL related to the NDA for meloxicam. The regulatory authority had stated that although the candidate met primary endpoints in clinical studies, analgesic effect failed to meet the FDA’s expectations based on data from ad hoc analyses and selective secondary endpoints. In October, the company re-filed the NDA following discussion with the FDA.

Recro Pharma stated that it strongly disagrees with the FDA and firmly believes that the non-opioid candidate (meloxicam) holds significant potential. The company remains committed to get regulatory approval for IV meloxicam and plans to meet the FDA to resolve the issues and discuss the path forward for the same.

In December 2018, the company amended its license agreement with Alkermes ALKS related to milestone payment on the approval of meloxicam. Previously, Recro Pharma was liable to pay $45 million to Alkermes on receiving the approval. The amended agreement allows Recro Pharma to spread the payment over seven years, which reduces cash requirement for 2019 by $30 million. The availability of more funds will help Recro Pharma to consistently support development and getting approval for meloxicam.

Recro Pharma is also evaluating the candidate in a phase III study for the treatment of pain following abdominoplasty surgery. The company is also developing intramuscular administration of meloxicam for acute pain.  The company has another clinical-stage pain candidate and an anesthetic candidate in its pipeline.

A potential approval to meloxicam will boost the company’s top-line performance as it may get better acceptance in the pain market due to prevalence of abuse of opioid-based drugs approved for treating pain.

However, the market for the pain drugs is crowded with availability of multiple drugs and several candidates under development based on different technologies which include Ocular Therapeutix’s OCUL Dextenza and Heron Therapeutics’ HTX-011.

Recro Pharma, Inc. Price

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Women’s Pain Is Different From Men’s—the Drugs Could Be Too

Men and women can’t feel each other’s pain. Literally. We have different biological pathways for chronic pain, which means pain-relieving drugs that work for one sex might fail in the other half of the population.

So why don’t we have pain medicines designed just for men or women? The reason is simple: Because no one has looked for them. Drug development begins with studies on rats and mice, and until three years ago, almost all that research used only male animals. As a result, women in particular may be left with unnecessary pain—but men might be too.

Now a study in the journal Brain reveals differences in the sensory nerves that enter the spinal cords of men and women with neuropathic pain, which is persistent shooting or burning pain. The first such study in humans, it provides the most compelling evidence yet that we need different drugs for men and women.

“There’s a huge amount of suffering that’s happening that we could solve,” says Ted Price, professor of neuroscience at the University of Texas, Dallas, and an author of the Brain article. “As a field, it would be awesome to start having some success stories.”

Modern-day pain control is notoriously dismal. Our go-to medicines—opioids and anti-inflammatories—are just new versions of opium and willow bark, substances we’ve used for thousands of years. Although they are remarkably effective in relieving the sudden pain of a broken bone or pulled tooth, they don’t work as well for people with persistent pain that lasts three months or longer.

Some 50 million people struggle with pain most days or every day, and chronic pain is the leading cause of long-term disability in the United States. Women are more likely than men to have a chronic pain condition, such as arthritis, fibromyalgia, or migraines.

Meanwhile, pain medications are killing us. About 17,000 people die each year from prescribed opioids as clinicians write almost 200 million opioid prescriptions, or more than one for every two American adults.

The failure to include sex differences in the search for better pain relief stems in part from flawed but deep-seated beliefs. “[Medical researchers] made the assumption that men and women were absolutely identical in every respect, except their reproductive biology,” says Marianne Legato, a cardiologist who began sounding an alarm in the 1980s about differences in heart attack symptoms among women. She went on to pioneer a new field of gender-specific medicine.

The physiology of pain is just one of many ways that men and women differ, she says. But she isn’t surprised that no sex-specific medicines have emerged. The medical community—including pharmaceutical companies—didn’t appreciate the variation between men and women, including in their metabolisms, immune systems, and gene expression. “If there were differences in how their drugs worked between men and women, they didn’t want to hear about it,” she says.

The Brain study came about from a unique opportunity at M.D. Anderson Cancer Center in Houston. You can’t take a biopsy of spinal tissue, but researchers were able to study clusters of sensory neurons in eight women and 18 men who had spinal tumors removed. The analysis included sequencing RNA to determine which genes are active in the neural cells. They compared men and women who had a history of chronic neuropathic pain to those who didn’t. Their pain wasn’t caused by the tumors themselves. Some patients had nerve compression causing neuropathic pain, while others didn’t have neuropathic pain or chronic pain at all.

In men who did have neuropathic pain, macrophages—cells of the immune system—were most active. In women, neuropeptides, which are protein-like substances released by neurons, were prominent. “This represents the first direct human evidence that pain seems to be as sex-dependent in its underlying biology in humans as we have been suggesting for a while now, based on experiments in mice,” says Jeffrey Mogil, professor of pain studies at McGill University in Montreal and a leading researcher on sex differences in pain, who was not involved in the Brain study.

Price and his colleagues emphasize that the finding needs further study. But it suggests that a new type of migraine drug that targets a neuropeptide known as CGRP might be broadly effective for chronic pain in women, he says. Women greatly outnumber men among migraine sufferers, and women made up about 85 percent of the participants in the Phase 3 clinical trials of the three anti-CGRP drugs approved by the Food and Drug Administration in 2018. Price wonders if the anti-CGRP drugs aren’t specific to migraines—but to women. His work with mice suggests that the drugs don’t work in males, but block pain in females. “CGRP is a key player in lots of forms of chronic pain in women, not just migraine,” he says.

Tailoring new medicines to men or women would be revolutionary, particularly considering that it took many years for women (and female animals) to get included in pain research at all. Fearful of potential birth defects, in 1977 the FDA cautioned against including women of childbearing age in clinical trials, which meant women used drugs solely designed for men. By 1993, the thinking had changed, and Congress passed a law requiring the inclusion of women in clinical trials funded by the National Institutes of Health. Although clinical trials now include both men and women, they often don’t report results by sex.

Meanwhile, animal researchers continued to use mostly male animals. As a graduate student in the 1990s, Mogil was killing time one day and decided to run some data separately for male and female mice—and discovered the drug the lab was testing worked only in males. When he excitedly told his supervisor, the post-doctoral neuroscientist responded, “Jeff, sex differences are to enjoy, not to study.” (He spent his career studying them, anyway.)

In a 2005 review of research in the journal Pain, Mogil found that 79 percent of pain studies involved only male animals. Only 4 percent looked for sex differences. In a huge leap forward, in 2016 the NIH began requiring most animal research it funds to involve both male and female animals—and to evaluate sex differences.

What is the legacy of the gender-blind research? Mogil once emailed a researcher, asking whether a pain drug worked better in men than women. The researcher didn’t know, and couldn’t pursue the question because the data was controlled by the pharmaceutical company. Mogil was left wondering if drugs that looked promising in male-only animal studies might have failed in clinical trials when the results were blended with those in women, depriving men of a viable treatment.

Medicines that could work best for women wouldn’t make it into the pipeline at all when basic science excluded female animals. Price wonders if unresolved pain among women might have led to their higher levels of chronic pain.

The acknowledgement of sex differences in pain could stir up the field and lead to new advances. Amid the promise of “personalized” medicine, with drugs tailored to patients based on genetic sequencing, developing pain medicines for half the population seems like a no-brainer. “Now there’s a whole new frontier opening up in front of our eyes,” Price says.

14 thoughts on “Pain Management Drugs

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